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Oxaliplatin ( ox-AL-i-pla-tin) belongs to the group of medicines called antineoplastics. It is used to treat cancer of the colon or rectum. Oxaliplatin is usually given along with other medicines to treat cancer.
Oxaliplatin interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Some of these may be serious and must be reported to your healthcare professional. Other effects may not be serious but may cause concern. Some effects may occur after treatment with oxaliplatin has been stopped. Be sure that you have discussed with your healthcare professional the possible side effects of this medicine as well as the good it can do.
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This medicine is available only with your healthcare professional's prescription, in the following dosage forms:
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your healthcare professional will make. For oxaliplatin the following should be considered:
Allergies - Tell your healthcare professional if you have ever had any unusual or allergic reaction to oxaliplatin or other medications or to platinum containing compounds (e.g. Platinol AQ [cisplatin], or Paraplatin [carboplatin]). Also tell your healthcare professional and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy - Oxaliplatin has not been studied in pregnant women. However, studies in animals have shown that oxaliplatin causes miscarriages, decreased weight or death of the fetus, and problems with bone formation. Be sure that you have discussed this with your healthcare professional before taking this medicine. Tell your healthcare professional right away if you think you have become pregnant while taking oxaliplatin.
Breast-feeding - It is not known whether oxaliplatin passes into human breast milk. Tell your healthcare professional if you are breast-feeding or if you intend to breast-feed during treatment with this medicine. Because oxaliplatin may cause serious side effects in the nursing infant, breast-feeding is not recommended while you are taking the medicine.
Children - Studies of this medicine have been done only in adult patients, and there is no specific information comparing the use of oxaliplatin in children with use in other age groups.
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Older adults - This medicine may increase your chance of getting certain side effects, such as diarrhea or dizziness, if you are 65 years of age or older.
Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your healthcare professional may want to change the dose, or other precautions may be necessary. When you are taking oxaliplatin, it is especially important that your healthcare professional and pharmacist know if you are taking any other medications.
Other medical problems - The presence of other medical problems may affect the use of oxaliplatin. Make sure you tell your healthcare professional if you have any other medical problems, especially:
Kidney disease - Effects of oxaliplatin may be increased because of slower removal from the body
This medicine often causes nausea and vomiting. However, it is very important that you continue to receive the medicine even if you begin to feel ill. Other medicines may be given to you to help with the nausea and vomiting. Ask your health care professional for other ways to lessen these effects.
The dose of oxaliplatin will be different for different patients. The dose that is used may depend on a number of things. Because this medicine can cause very serious side effects, your healthcare professional will be watching your dose very carefully and may change it as needed. If you have any questions about the proper dose of oxaliplatin, ask your healthcare professional.
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It is very important that your healthcare professional check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
While you are being treated with oxaliplatin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your healthcare professional's approval. Oxaliplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
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Oxaliplatin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
If you can, avoid people with infections. Check with your healthcare professional immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination and persistent diarrhea.
Check with your healthcare professional immediately if you have persistent vomiting, diarrhea, dehydration, cough or difficulty breathing
Check with your healthcare professional immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.
Check with your healthcare professional immediately if you notice any redness, pain, or swelling in the area you are receiving your medicine.
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